Although physicians frequently prescribe an analgesic or NSAID in addition to cyclobenzaprine, these studies were not designed to assess whether adding cyclobenzaprine provides a benefit over that of an analgesic. Results: One thousand four hundred five patients study 1; study 2 , two thirds with low back pain and one third with neck pain, were randomized to treatment.
Onset of relief was apparent within 3 or 4 doses of the 5-mg regimen. In the subanalysis of the proportion of responders in the pooled 5-mg groups who did and did not report somnolence, a meaningful treatment effect was observed on all primary efficacy variables in patients who did not report somnolence, suggesting that efficacy was independent of sedation.
Cyclobenzaprine was well tolerated. Rinse the mouth to make sure all of the medicine have been swallowed. Do not save any of the mixture to use later. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. This is more likely to happen in the few hours after you take it.
It can also have other side effects. If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.
This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. Cyclobenzaprine oral tablet can interact with other medications, vitamins , or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully.
Do not take monoamine oxidase inhibitors MAOIs with cyclobenzaprine. Doing so can cause dangerous effects in the body. Examples of these drugs include:. These include seizures. Taking cyclobenzaprine with certain medications raises your risk of side effects from cyclobenzaprine.
This is because the amount of cyclobenzaprine in your body is increased. When certain drugs are used with cyclobenzaprine, they may not work as well. An example of these drugs includes guanethidine. Cyclobenzaprine can block the blood pressure -lowering effect of guanethidine. This means your blood pressure may increase. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. This dosage information is for cyclobenzaprine oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly.
Though rare, deaths can occur from cyclobenzaprine overdose, especially in the case of multiple drug ingestion. The FDA recommends that doctors contact a poison control center for current information on treatment for an overdose, as the management of a case is complex.
The most common manifestations associated with overdose are drowsiness and an abnormally rapid heart rate tachycardia. Less common effects include body twitches tremor , the loss of control of bodily movements ataxia , hypertension, agitation, slurred speech, nausea, confusion, dizziness, hallucination, vomiting and coma. Rare but critical effects include cardiac arrest, chest pain and seizures. A formulation of cyclobenzaprine is now being tested to treat combat-related post-traumatic stress disorder PTSD.
Currently, it is in its third trial of drug testing and is being studied on military personnel. Research has found, so far, that the drug can help those with PTDS sleep better and have fewer nightmares. A , a double-blind randomized placebo-controlled study published by The Journal of Rheumatology found that the drug may also be useful in treating those with fibromyalgia sleep better. A drug used to deliver cyclobenzaprine into the body of fibromyalgia patients was recently halted during trials.
Other drugs using cyclobenzaprine are also being tested to treat fibromyalgia, though. The current form of cyclobenzaprine is not approved by the FDA for the treatment of fibromyalgia.
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